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目的:探讨高原地区T淋巴细胞亚群中CD分子在慢性阻塞性肺疾病(COPD)发病中的作用。方法:应用间接荧光免疫法测定居住于2 500m以上的COPD患者急性发作期、缓解期患者(每组20例)和健康对照者(15例)3组静脉血T淋巴细胞亚群CD3+、CD4+、CD8+百分率。结果:①急性期患者CD3+、CD4+百分率、CD4+/CD8+比值显著降低(P<0.05),CD8+百分率明显升高(P<0.05);②缓解期患者CD3+、CD4+百分率降低(P<0.05),CD8+细胞百分率略升高、CD4+/CD8+比值略降低(差别无统计学意义);③急性期与缓解期相比患者CD3+、CD4+百分率、CD4+/CD8+比值均有降低(P<0.05),CD8+百分率升高(P<0.05)。结论:慢性阻塞性肺疾病患者急性期和缓解期T细胞亚群中的CD3+、CD4+百分率、CD4+/CD8+比值均降低,CD8+百分率升高。
Objective: To investigate the role of CD molecules in the pathogenesis of chronic obstructive pulmonary disease (COPD) in T lymphocyte subsets in the plateau. Methods: The levels of CD3 +, CD4 + and T lymphocyte subsets in venous blood of 3 COPD patients living in more than 2500m were measured by indirect immunofluorescence method in acute phase of exacerbation, remission (20 cases) and healthy control group (15 cases) CD8 + percentage. Results: ①The percentage of CD3 +, CD4 + and CD4 + / CD8 + in acute phase were significantly decreased (P <0.05) and the percentage of CD8 + was significantly increased in remission (P <0.05) The percentage of CD3 +, CD4 + and CD4 + / CD8 + in the acute phase and the remission phase were significantly lower than those in the remission stage (P <0.05), and the percentage of CD8 + cells was slightly increased (P <0.05) High (P <0.05). Conclusion: The percentage of CD3 +, CD4 +, CD4 + / CD8 + T cells in acute and remission T cells in patients with chronic obstructive pulmonary disease are lower and the percentage of CD8 + is higher.