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目的 探讨蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)对体感诱发电位(SEP)的影响，及尼莫地平(ND)的保护作用。方法 对单纯SAH组和ND处理组大鼠观察手术前后基底动脉管径，并检测24h内局部脑血流量(rCBF)、SEP潜伏期及脑组织内皮素-1(ET-1)含量的动态变化。结果 SAH组大鼠在诱导SAH后rCBF立即降低，并持续24h，同时有基底动脉痉挛；SAH后1h开始至24h SEP潜伏期逐渐延长，脑组织ET-1含量显著增加。ND处理组大鼠上述变化均较轻。结论 SAH后CVS可通过脑血流的降低、脑组织ET-1增加而导致SEP潜伏期延长，ND通过拮抗脑组织ET-1变化而对之具有保护作用。
Objective To investigate the effect of cerebral vasospasm (CVS) on somatosensory evoked potential (SEP) after subarachnoid hemorrhage (SAH) and the protective effect of nimodipine (ND). Methods The diameters of basilar artery before and after operation were observed in SAH group and ND group. The changes of regional cerebral blood flow (rCBF), SEP latency and endothelin-1 (ET-1) content in brain were detected. Results In SAH group, rCBF decreased immediately after induction of SAH and continued for 24h, accompanied by basilar artery spasm. The latency of SEP gradually increased from 1 hour to 1 hour after SAH, and the content of ET-1 in brain tissue increased significantly. ND treatment group rats were lighter changes. Conclusions After SAH, CVS can prolong the latency of SEP through the decrease of cerebral blood flow and the increase of ET-1 in brain tissue. ND can protect against ET-1 through antagonizing the changes of brain ET-1.