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难治性癫痫严重危害着儿童的身心健康。不同作用机制、不同作用途径的治疗方法不断被推出。传统的抗癫痫药物疗效确切但副作用较大,且药物间相互作用较多,患者不易耐受。新型抗癫痫药物如左乙拉西坦、brivaracetam、Carisbamate等疗效显著且对肝功能损害小,药物间相互作用小;迷走神经刺激术、脑电刺激术、冷却法、放射疗法等物理疗法为难治性癫痫的治疗拓宽新的思路;改良后的生酮饮食疗法其临床实用性值得进一步研究。
Refractory epilepsy seriously endanger the physical and mental health of children. Different mechanisms of action, different ways of treatment has been introduced. The traditional antiepileptic drugs have definite curative effect, but have more side effects and more interactions among drugs, which are not easy for the patients to tolerate. New anti-epileptic drugs such as levetiracetam, brivaracetam, Carisbamate and other significant effect of liver damage and small, small drug interactions; vagus nerve stimulation, EEG stimulation, cooling, radiation therapy and other physical therapy as refractory Epilepsy treatment broaden new ideas; improved ketogenic diet therapy its clinical practical worth further study.