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目的:探讨小剂量高三尖杉酯碱联合干扰素治疗慢性粒细胞白血病的疗效。方法:13例初治费城染色体阳性慢性粒细胞白血病慢性期患者,应用羟基脲治疗,白细胞降至20×109/L时停用,给予高三尖杉酯碱0.7~1.2 mg/(m2.d),缓慢静脉滴注,5~14d/月,联合干扰素300万u,皮下注射,1次/2 d,3~6个月后维持量2次/周或1次/周,维持外周血中性粒细胞绝对值>1.5×109/L,血小板>60×109/L调整用药。每3个月复查染色体,6个月后以干扰素或羟基脲维持治疗。结果:13例患者中完全血液学缓解10例(76.92%),12个月完全遗传学缓解1例(7.69%),部分遗传学缓解2例(15.38%),微遗传学缓解2例(15.38%)。结论:小剂量高三尖杉酯碱联合干扰素治疗慢性粒细胞白血病可获得较高的血液学完全缓解和细胞遗传学缓解率,值得推广。
Objective: To investigate the effect of low dose homoharringtonine combined with interferon on chronic myeloid leukemia. METHODS: Thirteen patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia were treated with hydroxyurea. When leukocytes were decreased to 20 × 109 / L, the animals were sacrificed, and homoharringtonine was administered in an amount of 0.7-1.2 mg / (m2.d) , Slow intravenous infusion, 5 ~ 14d / month, combined interferon 3000000 u, subcutaneous injection, 1/2 d, 3 to 6 months after the maintenance dose 2 times / week or 1 / week, maintaining peripheral blood The absolute value of granulocytes> 1.5 × 109 / L, platelets> 60 × 109 / L adjust the medication. Chromosomes were reviewed every 3 months and maintained with interferon or hydroxyurea after 6 months. Results: Complete hematological remission in 10 patients (76.92%) in 13 patients, complete genetic remission in 12 months, 1 case (7.69%), partial genetics in 2 cases (15.38%), microgenetic remission in 2 cases %). Conclusion: High dose of homoharringtonine combined with interferon in treatment of chronic myelogenous leukemia can achieve higher hematological complete remission and cytogenetic remission rate, which deserves promotion.