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对不同制备工艺皮康冲剂中的盐酸小檗碱及黄芩甙含量 ,应用反相高效液相色谱法进行测定比较。结果表明 :黄连单独处理 ,于制粒前加入黄芩等药煎煮的稠膏中制得的冲剂 ,盐酸小檗碱及黄芩甙含量为最高 ,分别为 6.79% ,5 .3 0 % ;而黄芩、黄连等药合煎制得的皮康冲剂 ,盐酸小檗碱及黄芩甙含量为最低 ,分别为 0 .49% ,3 .1 9%。为皮康冲剂制备工艺优选提供了依据。
The content of berberine hydrochloride and jaundice in different preparations of Pikang Granules were determined by RP-HPLC. The results showed that the granules obtained from the single treatment of Coptis chinensis and the thick paste decocted with Huangqi and other drugs before granulation had the highest content of berberine hydrochloride and astragalus, which were 6.79% and 5.3% respectively; The content of Pican granules obtained by the combined decoction of Coptis chinensis, Coptis chinensis, berberine hydrochloride and jaundice was the lowest, which was 0.49% and 3.1%, respectively. It provides the basis for the preparation of Pikang Granules.