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目的探讨急性脑梗死病人T淋巴细胞亚群CD4+,CD8+,CD4+/CD8+的临床意义。方法应用流式细胞仪测定30例发病72h内急性脑梗死病人及健康体检者正常(对照组)血清中CD4+,CD8+,CD4+/CD8+水平,并根据神经功能缺损标准将脑梗死组分为轻、中、重3型,分析CD4+,CD8+,CD4+/CD8+与脑梗死轻重的关系。结果与正常对照组相比,急性脑梗死组中度、重度病人CD3+,CD4+,CD4+/CD8+显著降低,CD8+显著升高,而轻型脑梗死组变化不明显。结论急性脑梗死后病人免疫功能发生紊乱,并与其病情轻重有关,中度、重度脑梗死急性期病人存在显著的细胞免疫功能低下。
Objective To investigate the clinical significance of T lymphocyte subsets CD4 +, CD8 +, CD4 + / CD8 + in patients with acute cerebral infarction. Methods Serum levels of CD4 +, CD8 + and CD4 + / CD8 + were measured by flow cytometry in 30 patients with acute cerebral infarction within 72h after onset of illness and healthy controls. The cerebral infarction was divided into mild, Medium and heavy type 3, analyze the relationship between CD4 +, CD8 +, CD4 + / CD8 + and cerebral infarction severity. Results Compared with the normal control group, the levels of CD3 +, CD4 +, CD4 + / CD8 + and CD8 + were significantly increased in moderate and severe acute cerebral infarction patients, but not in mild cerebral infarction patients. Conclusions The immune function of patients with acute cerebral infarction is disturbed and related to the severity of the disease. The patients with moderate and severe acute cerebral infarction have significant cellular immune dysfunction.