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目的结合罗湖区女性风疹发病情况,重点研究育龄期妇女风疹发病情况及风疹血清IgG抗体水平,为控制风疹疫情,完善风疹免疫策略,预防先天性风疹综合征(CRS)提供科学依据。方法 2013年,在罗湖区体检中心随机抽取四家体检单位,筛选18~35岁育龄期妇女,采集血清标本共164份,用酶联免疫吸附法检测血清风疹IgG抗体,同时分析罗湖区2010-2013年女性风疹发病情况。结果 2013年,育龄期妇女风疹IgG抗体几何平均浓度和阳性率分别为103.1626 IU/ml和93.3%,各年龄组统计分析,差异无统计学意义(F=1.00,P=0.905;χ2=2.7668,P=0.2507);本市和外市的育龄期妇女风疹IgG抗体几何平均浓度和阳性率差异亦无统计学意义(F=0.207,P=0.991;χ2=0.0238,P=0.8774);有接种史、无接种史和接种史不详的育龄期妇女风疹IgG抗体阳性率和平均浓度差异无统计学意义(χ2=2.0691,P=0.3554;F=1.508,P=0.224)。2010-2013年罗湖区女性风疹发病年龄主要集中在15~35岁,占女性发病人数的74.84%,2010-2013年所占比例分别为75%、75.63%、75%、64.7%。结论对育龄期妇女加强接种风疹疫苗(或含有风疹疫苗的联合疫苗),提高育龄妇女风疹抗体水平,是控制小月龄发病和先天性风疹综合征的重要手段。
Objective To study the incidence of rubella in women of childbearing age and the level of serum IgG antibody in women of childbearing age in order to provide a scientific basis for the prevention of congenital rubella syndrome (CRS) and control the epidemic of rubella. Methods In 2013, four physical examination units were randomly selected in the Physical Examination Center of Luohu District to screen women of childbearing age from 18 to 35 years old. A total of 164 serum samples were collected and IgG antibodies to serum rubella were detected by enzyme-linked immunosorbent assay. The incidence of female rubella in 2013. Results The geometric mean and positive rates of rubella IgG antibodies in women of childbearing age in 2013 were 103.1626 IU / ml and 93.3%, respectively. There was no statistical difference between the age groups (F = 1.00, P = 0.905; χ2 = 2.7668, P = 0.2507). The geometric mean concentration and positive rate of rubella IgG antibody in women of childbearing age in this city and in other cities also showed no significant difference (F = 0.207, P = 0.991; χ2 = 0.0238, P = 0.8774) , No history of vaccination and vaccination history of women of childbearing age rubella IgG antibody positive rate and the average concentration was no significant difference (χ2 = 2.0691, P = 0.3554; F = 1.508, P = 0.224). The incidence of female rubella in Luohu District in 2010-2013 mainly ranged from 15 to 35 years old, accounting for 74.84% of the total number of female patients. The proportion of female rubella in 2010-2013 was 75%, 75.63%, 75% and 64.7% respectively. Conclusions It is an important method to control the incidence of juvenile age and congenital rubella syndrome in women of childbearing age to strengthen the rubella vaccine (or combination vaccine containing rubella vaccine) and raise the level of rubella antibody in women of childbearing age.