论文部分内容阅读
目的 了解咬合力减弱对大鼠磨牙牙周膜 (PDL) 型胶原 m RNA表达的影响。方法 采用拔牙法建立咬合力减弱的动物模型 ,运用原位杂交法检测实验组及对照组大鼠牙周膜 型胶原 m RNA的表达水平。结果 咬合力减弱后 6小时 ,PDL 内 型胶原 m RNA的表达水平 (49.7± 11.1)很快下降 (对照组 87.8± 19.1,P<0 .0 5 ) ,并在第 2天时达到最低 (2 3.7± 8.6 ,对照组 84.3± 14.0 ) ,第 3天时开始回升 (43.1± 10 .3,对照组 88.6± 14.7) ,到第 2周时回升到较高水平 (5 6 .3± 9.8) ,但仍低于正常咬合力组 (91.4± 16 .0 ,P<0 .0 5 ) ,实验组在第 3,4周时其表达水平同第 2周相当。 型胶原 m RNA的表达近牙侧强于骨侧。结论 型胶原 m RNA的表达水平与咬合力密切相关。
Objective To investigate the effect of decreased bite force on the mRNA expression of PDL collagen in rat molar. Methods Tooth occlusal force was used to establish animal model with reduced occlusal force. The expression of m RNA in periodontal ligament collagen of experimental group and control group was detected by in situ hybridization. Results The expression level of m RNA in PDL endosomes (49.7 ± 11.1) decreased rapidly (87.8 ± 19.1, P <0.05) at 6 hours after the bite force was weakened and reached the lowest level on the 2nd day (2 3.7 ± 8.6 in control group, 84.3 ± 14.0 in control group), began to rise on the third day (43.1 ± 10.3, 88.6 ± 14.7 in the control group), but rose to the higher level (56.3 ± 9.8) in the second week Still lower than the normal occlusal force group (91.4 ± 16.0, P <0.05). The expression level of the experimental group at the 3rd and 4th week was the same as that of the 2nd week. Collagen m RNA expression of the proximal teeth is stronger than the bone side. Conclusions The expression level of collagen m RNA is closely related to the occlusal force.