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[目的]观察和胃汤联合西药序贯治疗幽门螺杆菌相关性胃炎疗效。[方法]使用随机平行对照方法,将80例门诊患者按就诊顺序号抽签方法简单随机分为两组。对照组40例序贯疗法:前5d,奥美拉唑20mg/次+阿莫西林50mg/次,3次/d,口服;第6~10d,奥美拉唑20mg/次+阿莫西林50mg/次+克拉霉素1片/次+替硝唑10mg/次,2次/d,口服。治疗组40例和胃汤:谷芽、麦芽各15g,神曲、鸡内金、焦山楂、陈皮、莱菔子、佩兰各9g,枳壳、苏梗、桔梗、藿香各6g,甘草3g;乏力加党参、黄芪各9g;反酸加瓦楞子煅9g;胃痛加白芍9g,香附10g,水煎400mL,1剂/d,早晚分服;西药治疗同对照组。连续治疗10d为1疗程。观测临床症状、胃液pH、不良反应。连疗1疗程(10d),判定疗效。[结果]治疗组痊愈10例,显效10例,有效18例,无效2例,总有效率95.00%;对照组痊愈5例,显效8例,有效12例,无效15例,总有效率62.5%;治疗组疗效优于对照组(P<0.01)。胃液pH两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。不良反应发生率治疗组低于对照组(P<0.05)。[结论]和胃汤联合西药序贯治疗幽门螺杆菌相关性胃炎,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of sequential treatment of Helicobacter pylori-associated gastritis with Weizhi Decoction combined with western medicine. [Methods] Using randomized parallel control method, 80 outpatients were randomly divided into two groups randomly according to the lot number sequence of visiting doctor. The control group of 40 cases of sequential therapy: the first 5d, omeprazole 20mg / times + amoxicillin 50mg / times, 3 times / d, orally; 6 ~ 10d, omeprazole 20mg / times + amoxicillin 50mg / Times + clarithromycin 1 / times + tinidazole 10mg / times, 2 times / d, orally. The treatment group 40 cases and the stomach soup: Guya, malt 15g, Divine Comedy, Chikin gold, coke hawthorn, dried tangerine peel, razor clam, Peiran the 9g, Citrus aurantium, Suli, Campanulaceae, Agastache 6g, licorice 3g; Add 9g of Radix Codonopsis Pilosulae and Radix Astragali; 9g of acid reflux plus Radix Cladophila; 10mg of Radix Angelicae Sinensis and Radix Paeoniae Alba, 10g of Radix Angelicae Sinensis and 100mL of decoction. Continuous treatment of 10d for a course of treatment. Observation of clinical symptoms, gastric pH, adverse reactions. Treatment of 1 course of treatment (10d), determine the efficacy. [Results] In the treatment group, 10 cases were cured, 10 cases were markedly effective, 18 cases were effective, 2 cases were ineffective and the total effective rate was 95.00%. In the control group, 5 cases were cured, 8 cases markedly effective, 12 effective and 15 ineffective. The total effective rate was 62.5% The treatment group was better than the control group (P <0.01). Gastric pH was improved in both groups (P <0.01), and the treatment group improved better than the control group (P <0.01). The incidence of adverse reactions in the treatment group was lower than that in the control group (P <0.05). [Conclusion] Heliobacter pylori-associated gastritis is treated with HZT in combination with Western medicine, with satisfactory curative effect and no serious adverse reactions, which deserves promotion.