论文部分内容阅读
50例手术切除胃癌标本的癌旁粘膜,用4种多肽类激素和胺类抗血清,以 PAP 和 Gri-meliu’s 银染色方法,探测癌旁粘膜的神经内分泌细胞,发现1/3～1/2病例中有多种不同类型的神经内分泌细胞呈灶性增生,以 G 细胞增生为著,肠化腺的 EC 细胞为次,形态学上呈腺管状或微结节状排列,增生性质为单纯性而不是肿瘤性,但这种增生与胃癌并存,被认为是“胃癌高危”的标记,所以胃粘膜活检标本中探测 G 细胞病变有一定价值,G 细胞增生伴慢性萎缩性胃炎患者需紧密随访。
Fifty paracentesis specimens of paracancerous mucosa were surgically resected. Four types of peptide hormones and amine antisera were used to detect neuroendocrine cells in the paraneoplastic mucosa using PAP and Gri-meliu’s silver staining methods. 1/3 to 1/2 were found. There are many different types of neuroendocrine cells in the case of focal hyperplasia, with G cell hyperplasia, EC cells of the intestinal metaplasia, morphologically tubular or micronodular, the proliferation of simple Not neoplastic, but this hyperplasia coexists with gastric cancer and is considered to be a marker of “high risk for gastric cancer”. Therefore, it is of value to detect G cell lesions in biopsy specimens of gastric mucosa, and patients with G cell hypertrophy and chronic atrophic gastritis need close follow-up.