细菌的药物抗性是当今全球面临的主要公共健康威胁之一。抗药性相关的机制研究及对策已成为世界卫生组织和各国政府共同关注的问题。日前,中科院生物物理所张凯、赵永芳课题组合作,在抗生素耐药性研究领域取得进展,相关成果发布于《细胞研究》。细菌有多种形式的抗药机制,最普遍的一种机制是利用细胞膜上的多个药物外排泵,将抗生素外排出细胞。大肠杆菌MFS家族的多药物外排蛋白Mdf A是抗药机制研究中的范例,对该蛋白结构的解析有助于深入认识细菌的药物外排机制。张凯课题组成功解析了Mdf A-氯霉素以及 Bacterial drug resistance is one of the major public health threats facing the world today. The mechanism and mechanism of drug resistance have become the common concerns of WHO and other governments. Recently, the Chinese Academy of Sciences Institute of Biophysics Zhang Kai, Zhao Yongfang task force cooperation, made progress in the field of antibiotic resistance, the relevant results published in the “cell research.” Bacteria have various forms of resistance mechanisms, one of the most common mechanism is the use of multiple drug efflux pumps on the cell membrane, the antibiotic excreted cells. The multi-drug efflux protein Mdf A of the MFS family of Escherichia coli is an example of a drug resistance mechanism. The analysis of the protein structure helps to understand the bacterial efflux mechanism. Zhang Kai task force successfully analyzed Mdf A-chloramphenicol as well