A novel distributed tuned liquid damper (DTLD) for reducing vibration in structures is proposed in this paper. The basic working principle of the DTLDs is to fill the empty space inside the pipes or boxes of cast-in-situ hollow reinforced concrete (RC) floor slabs with water or other liquid. The pipes or boxes then work as a series of small TLDs inside the structure, to increase the damping ratio of the entire structural system. Numerical simulation that accounts for the fluid-structure coupling effect is carried out to evaluate the vibration-reduction efficiency of the DTLDs. The results show that the DTLDs are able to considerably increase the damping of the structure and thus reduce its vibration. An additional benefit is that the DTLDs do not require architectural space to be added to the structure.