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目的观察丁苯酞氯化钠注射液对一氧化碳中毒迟发性脑病患者认知功能的影响。方法将84例急性一氧化碳中毒迟发性脑病患者随机分成对照组和治疗组各42例,对照组给予常规药物加高压氧治疗,治疗组加用丁苯酞氯化钠注射液每次25mg,每天2次,共治疗14天。常规治疗持续30天,其中高压氧持续90天。采用MMSE及ADL评分对患者不同时间点的认知功能及日常生活能力进行评价,并进行组间及治疗前后比较。结果入院当天、14天、30天两组患者MMSE评分比较差异无显著性(P>0.05);治疗后90天治疗组评分明显高于对照组(P<0.05)。入院时、14天、30天两组患者ADL评分比较差异无显著性(P>0.05);与对照组比较,治疗后90天ADL评分有所降低,但差异无显著性(P>0.05)。结论丁苯酞氯化钠注射液可明显改善一氧化碳中毒迟发性脑病患者认知功能。
Objective To observe the effect of butylphthalide and sodium chloride injection on cognitive function in patients with delayed encephalopathy after carbon monoxide poisoning. Methods Eighty-four patients with delayed encephalopathy after acute carbon monoxide poisoning were randomly divided into control group and treatment group, with 42 cases in each group. The control group was given conventional therapy combined with hyperbaric oxygen therapy. The treatment group was given 25 mg sodium butyrate phthalate injection daily 2 times, a total of 14 days treatment. Routine treatment lasted 30 days, with hyperbaric oxygen lasting 90 days. The MMSE and ADL scores were used to evaluate the cognitive function and daily living ability of patients at different time points and compared before and after treatment. Results On the day of admission, there was no significant difference in MMSE score between the two groups on the 14th and 30th days (P> 0.05). The score of the 90th day after treatment in the treatment group was significantly higher than that in the control group (P <0.05). There was no significant difference in ADL score between the two groups on the 14th day and the 30th day after admission (P> 0.05). Compared with the control group, ADL score decreased on the 90th day after treatment, but there was no significant difference (P> 0.05). Conclusion Butylphthalide sodium chloride injection can significantly improve the cognitive function of patients with delayed encephalopathy after carbon monoxide poisoning.