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目的：初步探讨GDF-15在急性冠脉综合征(acute coronary syndrome ACS)患者中的表达规律及临床意义。方法：分别测定50名稳定型心绞痛(stable angina pectoris SAP)患者，50名ACS患者和30名对照患者血清生长分化因子-15(growth-differentiation factor-15 GDF-15)的浓度，计算其Gensini积分以及随访各组患者30天内的主要不良心血管事件(MACE)。结果：冠心病患者的GDF-15水平较非冠心病患者明显升高，且ACS组GDF-15水平升高较SAP组更显著，差异均有统计学意义(P值均＜0.05)；GDF-15与Gensini积分不存在相关性(P>0.05)；Logistic多因素回归分析发现GDF-15与30天内MACE关系密切(OR值为1.167)。结论：研究提示GDF-15浓度可能在ACS早期诊断、指导治疗和评估短期预后上有一定的临床意义。“,”Objective: The purpose of this study is to investigate the expression pattern of GDF-15 in patients with acute coronary syndrome and to assess its significance in clinic. Methods: 50 patients with stable angina pectoris (SAP) and 50 patients with acute coronary syndrome (ACS) were enrol ed as subjects and 30 individuals without ACS were served as control group. The level of serum growth-differentiation factor-15 (GDF-15) of each patient from SAP group, ACS group and control group was measured and the Gensini scores were calculated. The major adverse cardiovascular events (MACE) among patients from each group within 30 days were recorded during the clinical fol ow-up. Results: The GDF-15 level of patients with coronary artery disease (CAD) was higher than that of patients without CAD. Especial y, the level of GDF-15 in ACS group was significantly higher than that in SAP group. The difference in the two comparisons had significance in statistics (P<0.05). However, no correlation was observed between GDF-15 level and Gensini score. The result of multiple logistic regression analysis showed that the level of GDP-15 related to the occurrence of MACE within 30 days (The OR value was 1.167). Conclusions: The investigation suggested that the level of GDP-15 might have clinical significance in early diagnosis of ACS, guidance of treatment and evaluation of short-term prognosis of patients.