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目的:观察维金康口服液对尘肺引起的硅结节和肺弥漫性纤维化病变大鼠模型进行干预的结果。方法:45只大鼠,随机分为空白组、染尘组及染尘治疗组。空白组在正常环境中喂养;染尘组染尘同时,喂养一般饲料;染尘治疗组用30%维金康浓缩液1.0mL/100g,每日2次灌胃(人用量的33倍)。各组分别于实验第15、30、90天,分批处死5只大鼠,后解剖。结果:病理检测显示:染尘组第90d时表面有块状软骨样病变向肺表面突起。染尘治疗组、空白组两组大鼠肺部无异常发现。染尘治疗组体质量增长大于染尘组,鲜肺质量、干肺质量均小于染尘组。结论:维金康口服液对尘肺引起的硅结节和肺弥漫性纤维化有一定的治疗作用。
OBJECTIVE: To observe the effect of Weijinkang Oral Liquid on rats with pulmonary nodules and diffuse fibrosis induced by pneumoconiosis. Methods: Forty five rats were randomly divided into blank group, dyed group and dyed group. The blank group was fed in the normal environment. The dust group was dusted with the same amount of feed while the dust group was treated with 30% Vinkink concentrate 1.0 mL / 100 g twice daily (33 times of the human dosage). The rats in each group were sacrificed on the 15th, 30th and 90th days of the experiment respectively. Five rats were sacrificed in batches and dissected. Results: The pathological examination showed that on the 90th day of the dyed group, massive cartilage-like lesions appeared on the surface of the lung. Dust-treated group, blank group two groups of rats without abnormal lungs found. Dust treatment group body mass growth is greater than the dust group, fresh lung quality, dry lung quality are less than the dust group. Conclusion: Weijinkang oral liquid has certain therapeutic effect on pulmonary nodules and diffuse pulmonary fibrosis induced by pneumoconiosis.