鲨试验法用于复方拘檬酸钠注射液（下称检品）中细菌内毒素的检测，在规定的pH值范围内检品对鲨试验的凝胶反应有抑制作用，使检查结果呈假阴性而限制了该法的运用。目前国内仍规定用家兔法检查。根据尝试验检测细菌内毒素的灵敏度受检品pH值影响的原理，我们用无热原氢氧化钠 Shark test method for the compound sodium citrate injection (hereinafter referred to as the test) in the detection of bacterial endotoxin, within the specified pH value of the test shark test gel reaction inhibition, the test results were false Negative and limit the use of the law. At present, China still requires the use of rabbit test. According to try to test the sensitivity of bacterial endotoxin by the pH value of the test article, we use pyrogen-free sodium hydroxide