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目的:评价血管紧张素转换酶抑制剂苯那普利钠和AT_1受体拮抗剂缬沙坦联合应用对自发性高血压大鼠(SHR)的降压疗效及其逆转心肌肥厚作用和对肾素-血管紧张素-醛固酮系统(RAAS)、内洋地黄素水平的影响.方法:24只14周龄雄性SHR随机分成空白对照组、Benazepril组、Valsartan组和Benazepril+Valsartan组,另设WKY正常对照组.分别于药物干预前、药物干预后2、4、6、8周末测定大鼠SBP;于药物干预后8周末检测心肌组织和血浆肾素活性、血管紧张素Ⅱ浓度、心肌组织Na~+-K~+-ATP酶活性和内洋地黄素水平,并行心肌组织形态学检查.结果:药物干预各组SHR动脉收缩压(SBP)水平明显下降,尤以联合用药组SBP下降最显著;药物干预各组血浆和心肌组织肾素活性均明显升高;Benazepril组和Benazepril+Valsartan组血浆和心肌组织Ang Ⅱ水平降低,而Valsartan组血浆和心肌组织Ang Ⅱ水平则明显升高;随SBP水平的降低,心肌组织Na~+-K~+-ATP酶活性明显升高,而内洋地黄素水平则明显下降;药物干预各组LVM/BW、TDM均明显减低,尤以联合用药组改变最为显著.结论:ACEI Benazepril和AT_1拮抗剂Valsartan均有明显的降低SHR的SBP作用,能明显逆转左室肥厚;联合用药效果最为显著,并能有效防止单一AT_1拮抗剂所致血浆和心肌组织Ang Ⅱ水平的升高的副作
OBJECTIVE: To evaluate the antihypertensive effect of angiotensin converting enzyme inhibitor benazepril sodium and AT_1 receptor antagonist valsartan on spontaneously hypertensive rats (SHR) and its effect on the reversion of cardiac hypertrophy and the effect of renin - angiotensin - aldosterone system (RAAS) and endoxin levels.Methods: Twenty - four male SHRs were randomly divided into blank control group, Benazepril group, Valsartan group and Benazepril + Valsartan group, and another WKY normal control group Group.The SBP of rats were measured at the end of 2,4,6,8weeks before the drug intervention and at the end of the 8th week after drug intervention. The changes of myocardial tissue and plasma renin activity, the concentration of angiotensin II, the level of Na ~ + in myocardium, (P <0.05) .Conclusion: The myocardial systolic blood pressure (SBP) level of SHR decreased significantly in the intervention group, especially in the combination group The plasma and myocardial renin activities in each group were significantly higher than those in Benazepril group and Benazepril + Valsartan group, while Ang Ⅱ level in plasma and myocardial tissue of Valsartan group was significantly increased. With the increase of SBP level The activity of Na ~ + -K ~ + -ATPase in myocardium was significantly increased, while the level of endoxin was significantly decreased; LVM / BW and TDM were significantly decreased in all intervention groups, especially in combination group .Conclusion: Both ACEI Benazepril and AT1 antagonist Valsartan can significantly reduce the SBP of SHR and reverse left ventricular hypertrophy obviously. The combined effect is the most significant and can effectively prevent Angiotensin Ⅱ (Ang Ⅱ) in plasma and myocardium induced by single AT1 antagonist The elevated copy