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目的 探讨可溶性细胞间黏附分子 -1(sICAM -1)和白细胞介素 -8(IL -8)在哮喘发病中的作用。方法 应用酶联免疫吸附试验测定 3 0例哮喘和 2 0例健康对照组血清sICAM -1和IL -8。结果 急性发作期哮喘患者血清sICAM -1和IL -8明显高于缓解期哮喘患者及对照组〔sICAM分别为 (3 47 81± 81 2 3 ) μg/L ,(2 2 4 85± 17 1) μg/L ,(2 0 4 5 5± 2 7 43 ) μg/L ,P =0 0 0 0 ;IL -8分别为 (2 6 78± 16 19)ng/L ,(5 3 8± 4 7)ng/L ,(3 63± 0 5 3 )ng/L ,P =0 .0 0 0〕 ,而缓解期哮喘患者与对照组无明显差异 (P >0 0 5 )。结论 研究结果提示可溶性细胞间黏附分子 -1和白细胞介素 -8可能参与了哮喘急性发作期的发病过程。
Objective To investigate the role of soluble intercellular adhesion molecule-1 (sICAM-1) and interleukin-8 (IL-8) in the pathogenesis of asthma. Methods Serum levels of sICAM-1 and IL-8 in 30 asthmatic patients and 20 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA). Results Serum levels of sICAM-1 and IL-8 in patients with acute exacerbation of asthma were significantly higher than those in asthma patients and controls [sICAM (3 47 81 ± 81 2 3) μg / L, (2 2 85 ± 17 1) (2 0 45 ± 2 7 43) μg / L, P 0 0 0 0; IL -8 were (2 6 78 ± 16 19) ng / L, (5 3 8 ± 4 7 ) (ng / L, (3 63 ± 0 5 3) ng / L, P = 0.0000), while there was no significant difference between remission asthma patients and controls (P> 0.05). Conclusion The results suggest that soluble intercellular adhesion molecule-1 and interleukin-8 may be involved in the pathogenesis of acute exacerbation of asthma.