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目的 :研究一氧化氮 (NO)和内皮素 - 1(ET - 1)在 2型糖尿病性肾病 (DN)患者中的变化及苯那普利对其影响。方法 :选取 2型糖尿病 (DM)患者 119例 (男 5 6例 ,女 6 3例 )和正常对照组 30例 (男 16例 ,女 14例 ) ,抽取静脉血测NO和ET - 1水平。结果 :2型DM患者血浆NO明显低于正常人 (P <0 .0 5 ) ,血浆ET - 1和血管紧张素Ⅱ(AngⅡ )明显高于正常人 (P <0 .0 1) ;2型DN组血浆NO明显低于 2型DM组 (P <0 .0 1) ,血浆ET - 1和AngⅡ明显高于 2型DM组 (P <0 .0 1)。 2型DN组NO与ET - 1、AngⅡ、尿白蛋白排泄率 (UAER)呈负相关 ,ET - 1与AngⅡ、UAER呈正相关。苯那普利治疗后血浆NO明显升高 (P <0 .0 5 ) ,而ET - 1和AngⅡ则明显下降 (P <0 .0 5或P <0 .0 1)。结论 :NO与ET - 1失衡在DN的发生发展中起重要作用 ;苯那普利对肾脏有保护作用
Objective: To investigate the changes of nitric oxide (NO) and endothelin - 1 (ET - 1) in type 2 diabetic nephropathy (DN) and the effect of benazepril. Methods: A total of 119 patients (56 males and 63 females) and 30 normal controls (16 males and 14 females) were enrolled in this study. Serum levels of NO and ET - 1 were measured in patients with type 2 diabetes mellitus (DM). Results: Plasma NO in type 2 DM patients was significantly lower than that in normal subjects (P <0.05), plasma ET - 1 and Ang Ⅱ levels were significantly higher than those in normal subjects (P <0.01), type 2 Plasma NO in DN group was significantly lower than that in 2 DM group (P <0 01), plasma ET - 1 and Ang Ⅱ were significantly higher than those in 2 DM group (P <0 01). There was a negative correlation between NO and ET - 1, Ang Ⅱ and urinary albumin excretion rate (UAER) in type 2 DN group. ET - 1 was positively correlated with Ang Ⅱ and UAER. After benazepril treatment, plasma NO increased significantly (P <0.05), while ET - 1 and Ang Ⅱ decreased significantly (P <0.05 or P <0.01). Conclusion: The imbalance between NO and ET - 1 plays an important role in the occurrence and development of DN. Benazepril has a protective effect on the kidney