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采用细胞染色体畸变、血清生化毒理以及病理组织学方法，观察了四甲基吡嗪的慢性毒性作用。每日平均经饮水投予每只大鼠２０ｍｇ／ｋｇ体重的四甲基吡嗪，连续６个月。结果发现实验组和对照组相比，血清球蛋白减少（Ｐ＜０．０５），血清肌酐、血糖增加（Ｐ＜０．０５），７－乙氧基香豆素羟化酶活力有增加趋势，值得重视。对四甲基吡嗪作为保健类药物的作用，作出了否定性结论
Chronic toxicity of tetramethylpyrazine was observed using chromosomal aberrations, serum biochemical and pathological methods. An average of 20 mg / kg body weight tetramethylpyrazine per rat was administered via drinking water for 6 consecutive months. The results showed that compared with the control group, serum globulin decreased (P <0.05), serum creatinine and blood glucose increased (P <0.05), and the activity of 7-ethoxycoumarin hydroxylase increased , It is worth attention. On tetramethylpyrazine as a health care drugs role, made a negative conclusion