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甘露醇是临床上广泛应用的渗透性制尿剂,最近,有报道甘露醇本身可引起急性肾衰(ARF)。本文报道甘露醇中毒引起ARF的病例,并复习有关文献。病例 70岁患者因急性闭角性青光眼住院,经静脉甘露醇及口服醋唑磺胺治疗。既往有高血压、11型糖尿病、房颤及心梗病史,入院体检BP140/80mmHg,房颤已控制、无充血性心衰,入院时实验室检查BUN31mg％,Cr1.1mg％,血Na~-138mFq/L,K~-4.3mEq/L,Cl~-101mEq/L,HCO_3~-26mEq/L。入院后第4天早晨,已用了1000克甘露醇(20％甘露醇500mlqbh×10次)患者感气促不舒,BP160/105mmHg,心率120次/分,呼吸20次/分,二肿底可
Mannitol is a clinically widely used osmotic diuretic. Recently, it has been reported that mannitol itself can cause acute renal failure (ARF). This article reports mannitol poisoning caused ARF cases, and review of the literature. A 70-year-old patient was hospitalized for acute angle-closure glaucoma, treated with intravenous mannitol and oral azoxystrobin. Past history of hypertension, type 11 diabetes mellitus, history of atrial fibrillation and myocardial infarction, physical examination BP140 / 80mmHg, atrial fibrillation has been controlled, no congestive heart failure, admission to the laboratory BUN31mg%, Cr1.1mg%, blood Na ~ 138mFq / L, K ~ -4.3mEq / L, Cl ~ -101mEq / L, HCO_3 ~ -26mEq / L. On the morning of the fourth day after admission, the patients who had used 1000 grams of mannitol (20% mannitol 500mlqbh × 10 times) had no sensory stimulation, BP160 / 105mmHg, heart rate 120 beats / min, respiration 20 beats / can