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美国小儿肿瘤研究组报告708例男性急性淋巴细胞性白血病患儿在完成24-30个月的维持化疗后,行双侧睾丸楔形活检.73例(10.5%)有睾丸微小残留白血病浸润,其中单侧浸润19例,双测浸润54例.活检阴性的患儿随机分为停止治疗或再接受一年化疗;确诊为隐匿性睾丸白血病的患儿需接受包括长春新碱、强的松、左旋门冬酰胺酶在内的再诱导治疗.同时行双侧睾丸放疗(24cy),如睾丸超过5公分者,放疗量增加至30cy.中枢神经系统预防,用
The American Society of Pediatric Oncology reported 708 cases of acute lymphoblastic leukemia in children with bilateral testicular wedge biopsy after 24-30 months of maintenance chemotherapy and 73 cases (10.5%) of infants with minimal residual leukemia testis 19 cases of infiltration, double invasive infiltration of 54 cases of biopsy-negative children were randomized to stop treatment or receive one year of chemotherapy; children diagnosed with latent testicular leukemia required to receive, including vincristine, prednisone, Asparaginase re-induction therapy .At the same time bilateral testicular radiotherapy (24cy), such as testicular more than 5 cm, radiotherapy increased to 30cy.Central Nervous System Prevention, with