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目的:探讨右美托咪定防治剖宫产术中寒战的最适剂量。方法:将2013年1月至2016年12月在我院行剖宫产手术的120例产妇作随机分为A、B、C3组,分别予以0.3ug/kg、0.5ug/kg、0.8ug/kg右美托咪定静脉注入,观察3组患者术中寒战发生率与不良反应发生率的差异。结果:A组、B组、C组寒战发生率分别为为40.0%、12.5%、10.0%,B组、C组寒战发生率低于A组,差异有统计学意义(P<0.05),A组3级以上寒战发生率高于B组、C组,差异有统计学意义(P<0.05);B组、C组寒战发生率差异无统计学意义(P>0.05)。A组、B组、C组不良反应发生率分别为5.0%、7.5%、20.0%,A组、B组不良反应发生率低于C组,差异有统计学意义(P<0.05);A组、B组不良反应发生率差异无统计学意义(P>0.05)。结论:右美托咪定可以有效防治剖宫产术中寒战效果好,0.5ug/kg为最佳剂量。
Objective: To explore the optimal dosage of dexmedetomidine for preventing chills in cesarean section. Methods: From January 2013 to December 2016, 120 maternal women who underwent cesarean section in our hospital were randomly divided into three groups: A, B and C, respectively, and received 0.3ug / kg, 0.5ug / kg and 0.8ug / kg dexmedetomidine intravenous injection to observe the 3 groups of patients the incidence of chills surgery and the incidence of adverse reactions. Results: The incidence of chills in groups A, B and C were 40.0%, 12.5% and 10.0% respectively. The incidence of chills in groups B and C was lower than that in group A (P <0.05), and A The cholera incidence was higher in group B than in group C and group C (P <0.05). There was no significant difference in the incidence of chills between groups B and C (P> 0.05). The adverse reactions in group A, group B and group C were 5.0%, 7.5% and 20.0%, respectively. The incidence of adverse reactions in group A and group B was lower than that in group C (P <0.05) There was no significant difference in the incidence of adverse reactions in group B (P> 0.05). Conclusion: Dexmedetomidine can effectively prevent and treat cesarean section chills effect, 0.5ug / kg for the best dose.