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目的探讨盐酸阿比朵尔对病毒性心肌炎的治疗作用。方法以柯萨奇B3病毒构建小鼠病毒性心肌炎模型,灌胃给予盐酸阿比朵尔药液(高、中、低)3个剂量治疗7 d。然后观察各组小鼠生存率、血清心肌酶活性、心脏匀浆的病毒滴度以及心脏切片的病理变化并计算病理积分。结果与病毒对照组比较,治疗组的小鼠生存率明显增加,心肌病毒繁殖量明显降低,心肌酶活性明显下降,心肌炎病灶明显减轻。结论盐酸阿比朵尔对病毒性心肌炎具有一定的治疗作用。
Objective To investigate the therapeutic effect of abidol hydrochloride on viral myocarditis. Methods The mouse model of viral myocarditis was established by coxsackievirus B3 virus and intragastric administration of three doses of abidol hydrochloride solution (high, medium and low) for 7 days. Then observe the survival rate of mice in each group, serum myocardial enzyme activity, the virus titer of heart homogenate and pathological changes of heart sections and calculate the pathological score. Results Compared with the virus control group, the survival rate of mice in the treatment group was significantly increased, the reproduction of cardiomyocytes was significantly reduced, the activity of myocardial enzymes was significantly decreased, and the myocarditis lesions were significantly reduced. Conclusion Arbidol hydrochloride has a certain therapeutic effect on viral myocarditis.