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观察了噻氯匹啶（TP）对血小板聚集的影响，结果表明在体外可显著抑制ADP、花生四烯酸和凝血酶诱导的大鼠或人血小板聚集，其IC50分别为1．035、1.047和0．092mmol／L，在体内连到给药（TP：50－200mg／kg·d－1）7d可抑制ADP和凝血酶诱导的大鼠血小板聚单，提示TP是一个较强的血小板聚集抑制剂。
The effect of ticlopidine (TP) on platelet aggregation was observed. The results showed that ADP, arachidonic acid and thrombin-induced rat or human platelet aggregation were significantly inhibited in vitro with IC50 of 1.035, 1.047 and 0.092mmol / L, in vivo to the administration (TP: 50-200mg / kg · d-1) 7d can inhibit ADP and thrombin induced platelet aggregation in rats, suggesting that TP is a strong inhibition of platelet aggregation Agent.