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目的研究早产儿胃肠外营养相关性胆汁淤积症(PNAC)的危险因素。方法收集南方医科大学南方医院2006年1月-2015年12月危重症早产儿441例资料进行回顾性分析,根据是否发生PNAC分为PNAC组57例和非PNAC组384例,比较两组患儿出生体重、胃肠喂养开始时间、达到全胃肠营养时间等情况。根据胎龄及入院时间划分亚组进行分析比较PNAC的发生率。结果 PNAC发生率为12.93%。两组早产儿在胎龄、出生时体重、胃肠喂养开始时间、达到全胃肠营养时间等方面差异有统计学意义(P<0.05)。结论胎龄小、出生体重小、胃肠开始营养延迟等是PNAC的危险因素。应采用综合治疗措施减少PNAC的发生。
Objective To investigate the risk factors of parenteral nutrition-associated cholestasis (PNAC) in preterm infants. Methods The data of 441 cases of critically ill preterm infants from Southern Hospital of Southern Medical University from January 2006 to December 2015 were retrospectively analyzed. According to whether PNAC was divided into PNAC 57 cases and non-PNAC 384 cases, Birth weight, gastrointestinal feeding start time, to achieve total gastrointestinal nutrition time and so on. According to gestational age and admission time subgroups were analyzed and compared the incidence of PNAC. Results The incidence of PNAC was 12.93%. The preterm infants in both groups had significant differences in gestational age, body weight at birth, starting time of gastrointestinal feeding and total nourishing time (P <0.05). Conclusions The small gestational age, small birth weight, and delayed gastrointestinal nutrition are the risk factors for PNAC. Comprehensive treatment should be used to reduce the occurrence of PNAC.