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目的探讨不同剂型激素替代治疗对更年期女性的疗效和安全性。方法选取2015年10月-2016年10月到该院诊治的更年期女性120例,按照随机原则分为口服给药组、经皮给药组和经阴道给药组,每组40例。比较3组患者疗效和不良反应发生率。结果治疗前3组患者各项指标均未表现出明显差异(P>0.05);治疗后口服给药组和经皮给药组患者骨关节肌肉痛、抑郁Kupperman评分及总评分、骨密度及碱性磷酸酶水平、空腹血糖、甘油三酯、低密度脂蛋白及收缩压水平改善幅度均明显优于经阴道给药组(P<0.05);性交痛评分改善幅度明显次于经阴道给药组(P<0.05);口服给药组患者恶心呕吐、乳房胀痛、阴道不规则出血、肝酶升高和血脂异常等不良反应发生率相对较高(P<0.05);经皮给药组患者皮疹发生率相对较高(P<0.05)。结论不同剂型激素替代治疗对更年期女性均有确切疗效,临床应结合患者特点调整剂型,减少不良反应的发生。
Objective To investigate the efficacy and safety of different forms of hormone replacement therapy for menopausal women. Methods A total of 120 menopausal women were admitted to our hospital from October 2015 to October 2016. Randomly divided into oral administration group, transdermal delivery group and vaginal delivery group, 40 cases in each group. The efficacy and adverse reactions of the three groups were compared. Results There was no significant difference in each index between the three groups before treatment (P> 0.05). After treatment, the Kupperman score and total score of depression, bone mineral density and alkali The levels of phosphatase, fasting blood glucose, triglyceride, low density lipoprotein and systolic blood pressure were all significantly better than those of transvaginal group (P <0.05). The improvement rate of sexual pain score was significantly inferior to transvaginal group (P <0.05). The incidence of adverse reactions such as nausea and vomiting, breast tenderness, irregular vaginal bleeding, elevated liver enzymes and dyslipidemia in oral administration group was significantly higher than that in oral administration group (P <0.05) Rash incidence was relatively high (P <0.05). Conclusion Different dosage forms of hormone replacement therapy have the exact effect on the climacteric women, clinical should be combined with the characteristics of patients to adjust the dosage form, reduce the incidence of adverse reactions.