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本文报告了6例界线类麻风皮损中郎格罕氏细胞(LC)超微结构的变化。LC的数量有不同程度的减少,形态有些尚属正常,胞质内及其突起内可见多数郎格罕氏颗粒,同时其细胞核扭曲,胞质内无张力微丝,因此与周围的角朊细胞明显不同。有些LC有轻度变化,体积缩小,突起减少;变化较重者,突起几乎消失,细胞体呈圆或卵圆形,郎格罕氏颗粒少而小,线粒体明显变性,嵴断裂,空泡化乃至消失,部分核膜不清。有些LC胞质少,仅在核周围有少许胞质,有些似有破碎,但核仍呈不规则形。作者强调上述观察结果似可肯定以往所观察的现象,并提出LC在麻风发病机理中起重要作用。
This article reports the ultrastructural changes of Langerhans cells (LC) in 6 cases of boundary-lined leprosy lesions. The number of LCs was reduced to varying degrees. Some of the morphology was normal, with many Langerhans particles in the cytoplasm and its projections. At the same time, the nucleus was distorted, and there was no tension microfilaments in the cytoplasm, so the keratinocytes were surrounded with the surrounding keratinocytes. Significantly different. Some LCs have slight changes, the volume shrinks, and the projections decrease; in the heavier changes, the projections almost disappear, the cell bodies are round or oval, the Langerhans particles are small and small, the mitochondria are significantly degenerated, the tendon breaks, and vacuolization occurs. Even disappeared, and some nuclear membranes are unclear. Some LCs are cytoplasmic, with only a few cytoplasms around the nucleus and some appear to be broken, but the nucleus is still irregular. The authors emphasize that the above observations seem to confirm the phenomena observed in the past and suggest that LC plays an important role in the pathogenesis of leprosy.