论文部分内容阅读
目的比较白血病经大剂量化疗和常规剂量化疗两种缓解后治疗方案的肺部真菌感染率。方法选取经标准方案诱导达缓解的AML患者42例,ALL患者37例,其中AML患者经大剂量Ara-C进行缓解后治疗方案者23例,经标准DA或HA加或不加Vp-16作为缓解后治疗方案者19例,ALL患者经大剂量MTX或hyper-CVAD进行缓解治疗者21例,以经典VCDPA联合或不加L-asp作为缓解后治疗患者16例。结果经大剂量化疗的23例AML患者有11例感染真菌,经常规剂量化疗的19例AML患者有3例真菌感染;经大剂量化疗的21例ALL患者有10例感染真菌,经常规剂量化疗的16例ALL患者有5例真菌感染。AL患者经大剂量化疗真菌感染率明显高于常规剂量化疗患者,P<0.05,差异显著,AML患者与ALL患者化疗后真菌感染率差异不显著,P>0.05。结论AL患者经大剂量化疗真菌感染率明显高于常规剂量化疗患者。应加强抗真菌预防性或验性治疗。
Objective To compare the rates of lung fungal infection in two treatment regimens of leukemia treated with high dose chemotherapy and conventional dose chemotherapy. Methods Twenty-four patients with AML, 37 patients with ALL, were treated with standard regimen. Among them, 23 patients with AML treated with high dose Ara-C were treated with standard DA or HA plus or minus Vp-16 Twenty-nine patients with remission after treatment, 21 patients with ALL who were treated with high-dose MTX or hyper-CVAD, and 16 patients treated with classical VCDPA or without L-asp. Results Of the 23 AML patients treated with high-dose chemotherapy, 11 were infected with fungi. Of the 19 patients with AML treated with conventional chemotherapy, 3 had fungal infections. Of the 21 ALL patients treated with high-dose chemotherapy, 10 were infected with fungi and were treated with conventional chemotherapy Five of 16 patients with ALL had fungal infections. The prevalence of fungal infection in patients with AL was significantly higher than that of conventional chemotherapy (P <0.05). There was no significant difference in fungal infection rates between AL patients and ALL patients (P> 0.05). Conclusion The infection rate of fungal in patients with AL after high-dose chemotherapy is obviously higher than that of routine chemotherapy. Should be strengthened anti-fungal preventive or experimental treatment.