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目的探讨埃索美拉唑联合帕罗西汀治疗非糜烂性胃食管反流病的疗效。方法 92例非糜烂性胃食管反流病患者随机分为治疗组和对照组,治疗组46例,予埃索美拉唑20mg,1次/d;帕罗西汀20mg,1次/d;莫沙比利5mg,3次/d;对照组46例,予奥美拉唑20mg,1次/d,莫沙比利5mg,3次/d。疗程为8周。治疗2、4、6、8周时分别作症状评价。结果治疗后两组症状如反酸、烧心、胸痛疗效观察均有明显改善,治疗组疗效高于对照组(P<0.05)。结论埃索美拉唑联合帕罗西汀治疗非糜烂性胃食管反流病疗效优于同等剂量的奥美拉唑。
Objective To investigate the efficacy of esomeprazole combined with paroxetine in the treatment of non-erosive gastroesophageal reflux disease. Methods Ninety-two patients with non-erosive gastroesophageal reflux disease were randomly divided into treatment group and control group. The treatment group was treated with esomeprazole 20 mg once daily, paroxetine 20 mg once daily, Billy 5mg, 3 times / d; control group of 46 cases, to omeprazole 20mg, 1 / d, mosapride 5mg, 3 times / d. The course of treatment is 8 weeks. Treated 2, 4, 6, 8 weeks when symptoms were evaluated. Results After treatment, the symptoms of both groups such as acid reflux, heartburn and chest pain were significantly improved, and the curative effect in the treatment group was higher than that in the control group (P <0.05). Conclusion The efficacy of esomeprazole combined with paroxetine in the treatment of non-erosive gastroesophageal reflux disease is superior to that of omeprazole in the same dose.