目的研究同型半胱氨酸(total homocysteine,tHcy)水平在慢性肾衰竭(chronic renal failure,CRF)诊断中的应用。方法采用循环酶法测定127例CRF患者和138例健康人血浆tHcy的含量,并进行统计分析。结果血浆tHcy浓度CRF患者显著高于正常对照组(P<0.01),且Ⅴ期患者显著高于Ⅳ期患者(P<0.01),Ⅳ期患者显著高于Ⅲ期患者(P<0.01)。结论 CRF患者血浆tHcy浓度明显升高,且随着病情的加重,血浆tHcy浓度呈逐渐上升趋势,检测血浆tHcy浓度对了解CRF患者病情具有重要意义。 Objective To study the application of homocysteine ​​(tHcy) in the diagnosis of chronic renal failure (CRF). Methods The levels of plasma tHcy in 127 patients with CRF and 138 healthy controls were determined by circulating enzyme method and analyzed statistically. Results The level of plasma tHcy in CRF patients was significantly higher than that in normal controls (P <0.01), and the patients in stage Ⅴ were significantly higher than those in patients in stage Ⅳ (P <0.01). The patients in stage Ⅳ were significantly higher than those in stage Ⅲ patients (P <0.01). Conclusion The concentration of tHcy in plasma of patients with CRF is significantly higher than that in patients with CRF. With the progression of the disease, the level of tHcy in plasma gradually increases. The detection of tHcy in plasma is of great significance for understanding the condition of patients with CRF.