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目的 研究综合指标观察在门诊无痛胃镜日间镇静应用的安全性和科学性.方法 选择门诊自愿接受无痛胃肠镜检查患者100例,ASA I～Ⅱ级,随机分为A组和B组,每组50例,给予小剂量咪达唑仑与丙泊酚联合.在缓慢注药前提下,A组应用综合指标观察给药,B组按千克体质量给药.观察两组在不同操作点生命征变化,整个过程不良反应发生情况、操作满意度、人为干预情况,以及用药、操作时间、苏醒及离室时间.结果 两组短时间均出现了循环、呼吸的波动,与麻醉前比较差异有统计学意义(P＜0.05).B组体动增加,反复用药例数较多,操作时间延长、操作满意度不高.两组丙泊酚用量、操作时间、复苏及离室时间比较差异均有统计学意义(P＜0.05).两组均完成操作,无一例意外发生,当日出院.结论 咪达唑仑与丙泊酚联合应用,综合指标观察缓慢注药,在门诊无痛胃镜是安全可行的.但应警惕呼吸、循环不良事件发生.“,”Objective To study the comprehensive index in security,scientific painless gastroscope daytime sedation application.Methods One hundred cases of outpatient voluntarily accept painless gastrointestinal endoscopy patients,ASA Ⅰ-Ⅱ,were randomly divided into group A,group B,low dose midazolam and propofol were given.In the slow injection condition,group A had comprehensive index to observe the administration,group B was administered according to the weight in kilograms.The two groups were observed at different operating points of vital sign changes,occurrence of adverse reactions,the whole process of operation satisfaction,human intervention,and medication,operation time,recovery time and leave the room time.Results The two groups appeared circulation,respiratory fluctuations within a short period of time,there were significant differences compared with before anesthesia.Activity increased in group B,the cases of repeated drug use was more,operation time was prolonged and the operation of satisfaction was not high.The difference of two groups in the dosage of propofol,operation time,recovery and discharge time were signicant.The two groups all completed the procedure,there were no accident,same day discharge.Conclusions Midazolam combined with propofol,the comprehensive index of slow injection in clinic observation,painless gastroscopy is safe and feasible.But it should be wary of respiration,circulation of adverse events.