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目的:探讨整合调控技能训练对阿尔茨海默病(AD)患者生活质量的影响.方法:本研究设计是随机、开放、前瞻性对照研究.选取符合国际疾病分类第十版(ICD-10)中阿尔茨海默病确诊标准的住院患者共70例,随机分为研究组(常规精神科药物治疗+整合调控技能训练,n=35)和对照组(常规精神科药物治疗+空白对照,n=35),应用世界卫生组织生存质量测定量表简表(WHOQOL-BREF)、匹茨堡睡眠质量指数量表(PSQI)和简明精神病量表(BPRS)在0周,6周末进行盲法评估.结果:干预组和对照组各脱落1例.经6周干预后,研究组在WHOQOL-BREF总分、生理领域、心理领域、社会关系和环境领域得分均低于对照组(t=16.482,4.890,8.308,11.884,6.043;P＜0.05).研究组在PSQI总分、BPRS总分均显著高于对照组(t=3.571,2.025;P＜0.05).结论:整合调控技能训练能够有效的改善AD患者的睡眠质量及生活质量,促进其早日回归社会,值得临床推广应用.“,”Objective:To explore the effect of integrated regulation training(IRT)on quality of life for patients with Alzheimer disease(AD).Methods:In this randomized controlled,single blind,prospective study,70 patients with AD who met the edition international classification of diseases(ICD-10)criteria for AD,which were randomly assigned to treatment group(general drugs treatment combined with IRT,n =35),and control group(general drugs mono therapy,n =35).We used World Health Organization Quality of Life-Brief(WHOQOL-BREF),Pittsburgh Sleep Quality Index(PSQI)and Brief Psychiatric Rating Scale(BPRS) to blindly assessthe efficacy in two groups at 0 and 6 weeks.Results:There was one patient discontinuation between two groups,respectively.In the endpoint of treatment (at 6 weeks),regarding WHOQOL-BREF total score,physiological factor,psychological factor,and environment factor,there were significantly lower scores in the treatment group when compared with the control group(t =16.482,4.890,8.308,11.884,6.043;P ＜ 0.05).Furthermore,there were significantly higher scores in the treatmentgroup when compared with the control group on the total score of PSQI and BPRS(t =3.571,2.025;P＜0.05).Conclusion:Effects of IRT can effectively improve sleep and the quality of life in patients with AD,which will pose a new way to early rehabilitation of AD patients,deserving further clinical applications.