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应用大剂量α—干扰素(IFN—α)治疗20例慢性乙型肝炎(慢乙肝)患者,检测治疗前后血清层粘蛋白(LN)的含量变化,以期评价IFN—α对慢乙肝纤维化改善的效果,现报告如下。 1 资料与方法 1.1 临床资料 40例慢性乙型肝炎患者均为我院传染科确诊的住院病人,其中20例自愿应用大剂量IFN—α诱导治疗为治疗组;20例不用IFN—α,以经典保肝方案治疗者为对照组。年龄范围8～45
20 patients with chronic hepatitis B (chronic hepatitis B) were treated with high-dose interferon-α (IFN-α) to detect the changes of serum laminin (LN) before and after treatment to evaluate the effect of IFN-α on the improvement of chronic hepatitis B The results are as follows. 1 Materials and Methods 1.1 Clinical data 40 cases of chronic hepatitis B patients were hospitalized infectious patients confirmed inpatient, 20 cases of volunteered application of high-dose IFN-α induction therapy for the treatment group; 20 cases without IFN-α, with classic Hepatoprotective treatment for the control group. The age range of 8 ~ 45