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介绍不同钚化合物由不同途径进入体内的致癌效应研究。研究结果表明:(1)钚确系具有高度致癌毒性的放射性核素;(2)低水平硝酸钚可诱发大鼠骨肉瘤,在185kBq·kg~(-1)组肿瘤发生率为38.9％～42.9％;(3)二氧化钚可诱发大鼠肺癌(主要是鳞状细胞癌),对胸部淋巴结的生物效应值得引起关注;(4)钚、锶、铈多种核素复合作用下,其诱发效应大于单一核素的作用,可呈现相加效应或协同效应;(5)通过比较毒理学的方法,从动物资料外推到人,估计钚致人体骨内瘤的危险度为600/(10~6人·cGy),并对此危险度值结合国内外资料进行评论。上述研究结果,对评价钚对人体潜在危害是具有重要参考价值的。
This paper introduces the carcinogenic effects of different quinone compounds entering the body from different pathways. The results of the study showed that: (1) 钚 is indeed a highly toxic carcinogen radionuclide; (2) low-level lanthanum nitrate can induce osteosarcoma in rats, and the incidence of tumor in the 185kBq·kg-1 group is 38.9% ～ 42.9%; (3) Cerium dioxide can induce rat lung cancer (mainly squamous cell carcinoma), and the biological effects on chest lymph nodes deserve attention; (4) Under the combined action of various nuclides of plutonium, plutonium, and indole, The evoked effect is greater than the effect of a single nuclides, and can present an additive effect or a synergistic effect. (5) The estimated risk of human osteoid tumors is 600/(5), through extrapolation of toxicological methods from animal data to humans. 10 to 6 people cGy), and comment on this risk value in combination with domestic and foreign data. The above research results are of important reference value for the evaluation of potential harm to human body.