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从哺乳动物体细胞染色体损仿规律外推到生殖细胞染色体损伤程度,是研究电离辐射对人类遗传危害评价中的一个重要问题。本综述在介绍辐射诱发哺乳类动物生殖细胞染色体畸变规律的基础上,重点讨论了辐射诱发生殖细胞和体细胞染色体畸变规律性的比较。辐射诱发精原细胞染色体易位的剂量—效应关系较明确,为峰性曲线;不同种属动物的效应曲线峰值不同,人为2Gy、罗猴为2～3Gy,而小鼠为6Gy,
Extrapolation of mammalian somatic chromosome damage rules to germ cell chromosomal damage is an important issue in the study of the evaluation of human genetic hazards caused by ionizing radiation. In this review, based on the introduction of radiation-induced chromosome aberrations in germ cells of mammals, we focus on the comparison of the regularity of chromosome aberrations between germ cells and somatic cells induced by irradiation. The dose-effect relationship of radiation-induced chromosomal translocation of spermatogonia was more clear and peak-shaped. The peak of effect curve was different in different species of animals, with 2 Gy for humans and 2 to 3 Gy for rhesus monkeys and 6 Gy for mice,