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目的:探讨儿童发生抗生素相关性腹泻(AAD)的相关危险因素,为临床诊治提供参考。方法:将2011年1月~2013年12月该院收治的60例AAD患儿列为观察组,选择同期60例无ADD儿童列为对照组。对比两组患儿基本资料、免疫功能、抗生素使用等情况,多因素对象实施Logistic回归分析。结果:观察组年龄[(0.94±0.51)岁]、营养不良(31.67%)、免疫受损(45.00%)、抗生素种类(3.49±0.84)、抗生素使用时间[(3.49±0.84)天]与对照组比较,差异均有统计学意义(t=4.135,P=0.024;χ2=7.854,P=0.007;χ2=11.015,P=0.001;t=7.564,P=0.008;t=4.445,P=0.020);多因素回归性分析结果显示,免疫功能受损(P=0.004,95%CI=-0.169~0.032)、抗生素种类多(P=0.001,95%CI=-0.159~0.079)、抗生素使用时间长(P=0.002,95%CI=-0.163~0.045)是发生AAD危险因素。结论:低龄、营养不良、免疫受损、抗生素种类多、抗生素使用时间长易引起AAD,其中免疫功能受损、抗生素种类多、抗生素使用时间长是危险因素,应积极干预。
Objective: To explore the risk factors of antibiotic-associated diarrhea (AAD) in children and provide reference for clinical diagnosis and treatment. Methods: From January 2011 to December 2013, 60 children with AAD admitted to our hospital were selected as the observation group. 60 children without ADD were selected as the control group. Comparing two groups of children’s basic information, immune function, antibiotic use and so on, multi-factor object implementation Logistic regression analysis. Results: The age of the observation group was significantly higher than that of the control group [(0.94 ± 0.51) years], malnutrition (31.67%), immunocompromised (45.00%), antibiotic species (3.49 ± 0.84), antibiotic use time The difference was statistically significant (t = 4.135, P = 0.024; χ2 = 7.854, P = 0.007; χ2 = 11.015, P = 0.001; t = 7.564, P = 0.008; ; Multivariate regression analysis showed that immune function was impaired (P = 0.004, 95% CI = -0.169-0.032), antibiotic variety (P = 0.001,95% CI = -0.159-0.079), antibiotic use time (P = 0.002, 95% CI = -0.163 ~ 0.045) was the risk factor for AAD. Conclusion: Aged, malnutrition, immune damage, many types of antibiotics, antibiotics use a long time easily lead to AAD, which impaired immune function, antibiotics and antibiotics use a long time is a risk factor, should be actively intervened.