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目的:研究糖耐量受损后认知功能障碍的变化及关系分析。方法:选取有糖耐量受损患者和同时住院的正常患者进行对比研究,在排除年龄、性别、血压等基本因素的影响后,对2组在基线、随访1、2年后的血糖变化和认知功能障碍进行相关性的研究。结果:各组患者在基本资料情况的比较中无差异统计,随着年限的增加,2组患者的空腹血糖和2小时PG均有不同程度的升高,但2组之间的比较不具有差异(P>0.05),其中A组组内之间的比较具有差异比较,而B组则不具有此比较。对于MMSE和Mcoa的评分,随着年限的增加,2组的认知功能出现不同程度的退化,而A组要比B组更加明显,2组比较具有比较意义,A组组内之间的比较也具有差异,并且,血糖水平越高,认知功能水平越低,得老年痴呆的几率就越大,B组则不具有此差异。结论:IGT严重的患者产生认知功能障碍的机率越大,对IGT患者进行认知功能的预防和锻炼,减少认知功能障碍的发生率,节约人力资源。
Objective: To study the changes of cognitive dysfunction after impaired glucose tolerance and the relationship analysis. Methods: A comparative study of patients with impaired glucose tolerance and hospitalized patients was conducted. After excluding the influence of age, gender, blood pressure and other basic factors, the changes of blood glucose at baseline, Knowledge of dysfunction related research. Results: There was no difference between the groups in the comparison of basic data. With the increase of the number of years, fasting blood glucose and 2-hour PG were increased to some extent in both groups, but no significant difference was found between the two groups (P> 0.05), among which the comparison between groups A and B was not compared with that of group B. For the MMSE and Mcoa scores, with the increase of the number of years, the cognitive function of the two groups showed different degrees of degeneration, but the A group was more obvious than the B group, the two groups were more meaningful, the comparison among the A groups There are also differences, and, the higher the blood glucose level, the lower the level of cognitive function, the greater the chances of dementia, B group did not have this difference. Conclusion: The greater the probability of cognitive impairment in patients with severe IGT, the prevention and exercise of cognitive function in patients with IGT, the reduction of the incidence of cognitive dysfunction, and the reduction of human resources.