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目的 :研究二巯基敌枯双所致甲状腺的形态改变 ,探讨二巯基敌枯双是否属甲状腺激素干扰物。方法 :Wistar大鼠 60只 ,随机分为正常对照组和实验组。正常对照组给予溶剂二甲基亚砜 ,实验组给予二巯基敌枯双二甲基亚砜溶液 ,剂量为 5 0 mg/kg体重。于实验组的给药第 5 d、第 10 d和第 2 0 d,分别放血处死两组动物。测定血清中 T4,TSH的浓度 ;取动物甲状腺称重 ,常规 HE染色 ,光镜下观察。结果 :各时间点实验组血清 T4,TSH的浓度和对照组相比无显著变化 (P>0 .0 5 ) ;实验组动物的甲状腺脏器系数显著高于对照组 ,(P<0 .0 5 ) ;组织学观察到实验组在第 5 d甲状腺滤泡上皮增生 ,有的滤泡出现局灶性增生斑块 ,第 10 d复层化的甲状腺滤泡上皮细胞继续增生 ,并向间质突出 ,形成实心芽 ,第 2 0 d实心芽向继发滤泡分化 ,出现了滤泡腔。结论 :二巯基敌枯双引起甲状腺增生 ,提示具有甲状腺激素干扰物的可能性
OBJECTIVE: To study the morphological changes of thyroid gland induced by dimercaptosuccinimide and investigate whether thyrotropin disulfide is involved in dimercaptopropionate. Methods: Sixty Wistar rats were randomly divided into normal control group and experimental group. The normal control group was given solvent dimethylsulfoxide, the experimental group was given dimethyl sulfoxide dimethyl sulfoxide solution, the dose of 50 mg / kg body weight. In the experimental group on the 5th, 10th and 20th day, two groups of animals were sacrificed by exsanguination. Determination of serum concentration of T4, TSH; animals were weighed thyroid, conventional HE staining, light microscopy. Results: The concentrations of T4 and TSH in the experimental group were not significantly different from those in the control group at each time point (P> 0.05). The thyroid organ coefficient in the experimental group was significantly higher than that in the control group (P <0. 0 5). Histology was observed in the experimental group on the 5th d thyroid follicular epithelial hyperplasia, some follicular focal hyperplasia plaques, 10 d stratified thyroid follicular epithelial cells continue to proliferate, and to the stromal Prominent, the formation of solid buds, 20d solid bud to secondary follicular differentiation, the emergence of the follicular cavity. CONCLUSIONS: Dimercapramine double causes thyroid hyperplasia, suggesting the possibility of thyroid hormone disruptors