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目的：探索提高恶性脑胶质瘤治疗效果的新途径；方法：用人参皂甙（Ｇｉｎｓｅｎｏ－ｓｉｄｅ，ＧＳ）与白细胞介素２（ＩＬ－２）协同诱导人外周血单个核细胞（ＰＢＭＣ）制成ＧＳ－ＬＡＫ细胞，用ＭＴＴ法测定其对恶性脑胶质瘤细胞（ＢＴ３２５）的杀伤活性，并与ＬＡＫ细胞相比较；结果：效应细胞ＧＳ－ＬＡＫ在增殖数量和杀伤恶性脑胶质瘤细胞活性等方面均优于ＬＡＫ细胞，且ＩＬ－２用量减少；结论：采用ＧＳ－ＬＡＫ细胞，可提高效应细胞的数量和活性，为恶性脑胶质瘤的免疫治疗打下了理论基础
OBJECTIVE: To explore a new way to improve the therapeutic effect of malignant glioma.METHODS: Human peripheral blood mononuclear cells (PBMCs) were induced by Ginseno-side (GS) and interleukin-2 (IL-2) GS-LAK cells. MTT assay was used to determine the cytotoxic activity against BT-251 cells and compared with that of LAK cells. RESULTS: The proliferation of effector cells GS-LAK and the activity of killing malignant glioma cells And other aspects are superior to LAK cells, and the amount of IL-2 reduced; Conclusion: The use of GS-LAK cells can increase the number of effector cells and activity of the malignant glioma immunotherapy laid the theoretical foundation