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采用短程的大剂量的促肾上腺皮质激素疗法,已证明对重症肌无力患者是有用的措施,特别是对那些用抗胆碱酯酶药物不能充分控制的患者。皮质类固醇对重症肌无力的治疗一般都报告是无效的。大多数的早期研究指出在用药过程中肌力或者无改变或者减弱,其后亦无改善。我们采用大剂量的甲基强地松龙对9例重症肌无力患者进行了42个疗程的治疗以确定其对本病的疗效,并阐明促肾上腺皮质激素对本病的作用是否通过肾上腺皮质。
The use of short-term, high-dose corticosteroid therapy has proven to be a useful treatment for patients with myasthenia gravis, especially in those who are not adequately controlled by anticholinesterase drugs. Corticosteroids are generally reported as ineffective in the treatment of myasthenia gravis. Most of the early studies indicated that muscle strength either did not change or was weakened during the course of medication and did not improve thereafter. We administered a large dose of methylprednisolol to 9 patients with myasthenia gravis for 42 courses of treatment to determine their efficacy against this disease and to elucidate whether adrenocorticotrophic effects on this disease pass through the adrenal cortex.