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目的：通过测定左氟沙星对常见感染性细菌的最低抑菌浓度（ＭＩＣｍｇ／Ｌ）和最低杀菌浓度（ＭＢＣｍｇ／Ｌ）以了解其体外抗菌作用。方法：采用平皿二倍稀释法测定ＭＩＣ；采用影印培养法测定ＭＢＣ；并测定条件因素对体外药效学的影响。结果：左氟沙星对革兰氏阳性球菌中的ＭＲＳＡ、ＭＳＳＡ、ＭＲＳＥ、ＭＳＳＥ的ＭＩＣ９０为４０，０５，８０，１０ｍｇ／Ｌ，对以大肠杆菌为代表的肠杆菌科细菌的ＭＩＣ低于２ｍｇ／Ｌ，对厌氧菌ＭＩＣ５０为２～４ｍｇ／Ｌ。结论：左氟沙星对绝大多数临床感染细菌具有极强抗菌作用，不仅能抑制需氧菌或兼性厌氧菌，对常见厌氧菌也有抗菌作用。
OBJECTIVE: To determine the antibacterial activity of levofloxacin in vitro by measuring MICmg / L and MBCmg / L of common infectious bacteria. Methods: MIC was determined by two-fold dilution of plate; MBC was determined by photocopy culture method; and the influence of conditional factors on pharmacodynamics in vitro was determined. Results: MIC90 of levofloxacin against MRSA, MSSA, MRSE and MSSE in Gram-positive cocci was 40,05,80,10mg / L, Bacillus bacteria MIC is less than 2mg / L, the anaerobic MIC50 is 2 ~ 4mg / L. Conclusion: Levofloxacin has strong antibacterial effect on the vast majority of clinically infected bacteria, which can not only inhibit aerobic bacteria or facultative anaerobes, but also have antibacterial effects on common anaerobic bacteria.