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陕西省肿瘤医院 ,西安 71 0 0 612 陕西省人民医院 ,西安 71 0 0 68目的 观察抑癌基因P16、增殖细胞核抗原PCNA在食管鳞状细胞癌中的表达特性及与临床病理联系。方法 应用SP免疫组织化学方法。结果 在 6 4例食管鳞癌中P16阳性表达率为 6 8 9% ,PCNA阳性细胞增殖指数 (PCNA PI)平均值 5 3 4。P16在低分化癌中较高分化癌阳性表达率低 ,相反 ,PCNA PI在高分化癌平均值低 ,在低分化癌高 (P <0 0 5 )。有淋巴结转移的P16阳性表达率低 ,且随着病期的进展阳性表达率降低 (P <0 0 5 )。P16阴性组PCNA PI高 (P >0 0 5 )。结论 联合检测P16蛋白和PCNA蛋白对食管鳞癌恶性度评定 ,治疗的选择 ,预后估计有重要意义
Shaanxi Provincial Cancer Hospital, Xi’an 71 0 0 612 Shaanxi Provincial People’s Hospital, Xi’an 71 0 0 68 Objective To investigate the expression characteristics of tumor suppressor gene P16 and proliferating cell nuclear antigen PCNA in esophageal squamous cell carcinoma and its relationship with clinicopathology. Methods SP immunohistochemical method was used. Results The positive expression rate of P16 in 64 cases of esophageal squamous cell carcinoma was 68.9%, and the mean value of PCNA positive cell proliferation index (PCNA PI) was 534. The positive rate of P16 in poorly differentiated carcinomas was higher in differentiated carcinomas. On the contrary, PCNA PI was low in well-differentiated carcinomas and high in poorly differentiated carcinomas (P < 0.05). The positive expression rate of P16 with lymph node metastasis was low, and the positive expression rate decreased with the progression of the disease (P < 0.05). The PNA negative group had a high PCNA PI (P > 0 05). Conclusion The combined detection of P16 protein and PCNA protein has important significance for the evaluation of malignant degree of esophageal squamous cell carcinoma, choice of treatment, and prognosis estimation.