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目的：观察多沙普仑对犬失血性休克等容输血后血流动力学的影响。方法：犬分为对照组和多沙普仑组（只数均＝５）。股动脉快速放血３０ｍｌ／ｋｇ，造成严重休克模型，３０分钟后等容输血。多沙普仑组输血后立即静脉注射多沙普仑２ｍｇ／ｋｇ。用Ｓｗａｎ－Ｇａｎｚ漂浮导管等方法分别于休克、输血前后测定血流动力学参数。结果：休克后５分钟、３０分钟ＭＡＰ、ＣＯ、ＣＩ、ＳＶ、ＬＶＳＷ、ＬＶＳＷＩ明显下降，ＳＶＲ明显增高。输血后１５分钟，多沙普仑组已恢复到休克前水平，但对照组则未能恢复。结论：多沙普仑能促进失血性休克等容输血后循环功能的恢复。
Objective: To observe the effects of doxapram on hemodynamics after isovolemic transfusion in hemorrhagic shock in dogs. Methods: Dogs were divided into control group and doxapram group (all only = 5). Femoral artery rapid bleeding 30ml / kg, resulting in severe shock model, isovolumic blood transfusion 30 minutes later. Doxapram received intravenous doxapram 2 mg / kg immediately after transfusion. Swan-Ganz floating catheter and other methods were measured before and after the shock, blood transfusion hemodynamic parameters. Results: The levels of MAP, CO, CI, SV, LVSW and LVSWI decreased obviously and the SVR increased obviously at 5 and 30 minutes after shock. Fifteen minutes after transfusion, the doxapram group had recovered to pre-shock levels, but the control group failed to recover. CONCLUSION: Doxapram can promote the recovery of circulatory function after isovolemic hemorrhagic shock.