论文部分内容阅读
目的:探讨TGF-α、EGFR表达与胰腺癌神经浸润转移的关系。方法:用免疫组织化学方法检测31例胰腺癌及其对应癌旁组织中TGF-α、EGFR蛋白表达水平。结果:EGFR蛋白表达水平与胰腺癌神经浸润转移相关(P<0．05)。胰腺癌中有神经浸润转移者TGF-α、EGF R共同表达为12例(63．16％),无神经浸润转移者共同表达为2例,其间的差异具有统计学意义(P<0．05)。结论:EGFR蛋白的过量表达,TGF-α／EGFR自分泌环可能在胰腺癌神经浸润转移中也起重要作用。
Objective: To investigate the relationship between TGF-α, EGFR expression and neural invasion and metastasis of pancreatic cancer. Methods: Immunohistochemical method was used to detect the expression of TGF-α and EGFR in 31 cases of pancreatic cancer and corresponding paracancerous tissues. Results: The expression of EGFR protein was correlated with the invasion and metastasis of pancreatic cancer (P <0.05). There were 12 cases (63.16%) of TGF-α and EGF R shared by nerve infiltration in pancreatic cancer, and 2 cases expressed by EGFR (P <0.05) ). Conclusion: Overexpression of EGFR protein and TGF-α / EGFR autocrine loop may play an important role in the invasion and metastasis of pancreatic cancer.