为评估生化预防法的效果 ,毒性反应及其与生物学标志调控的相关性 ,该作者选择 36例活检证实为上呼吸道或消化道重度癌前病变者进行研究。 36例中喉部病变 2 3例 ,口腔和口咽部病变 13例。男性 2 7例 ,女性 9例。平均年龄 58岁 (33～ 79岁 )。治疗前停用视黄醛类药物 3个月 ,治 To assess the effectiveness of biochemical prophylaxis, toxicity, and its relevance to the regulation of biomarkers, the authors selected 36 biopsy patients who were confirmed to have severe precancerous lesions of the upper respiratory tract or digestive tract. Of the 36 cases, 23 cases had laryngeal lesions and 23 cases had oral and oropharyngeal lesions. There were 27 males and 9 females. The average age is 58 years old (33-79 years old). Disable retinal drugs for 3 months before treatment, treatment