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目的 探讨联合检测肿瘤相关物质联合检测试剂盒 (TSGF)、CA12 5及 CA199在卵巢癌诊断、疗效观察中的价值。方法 采用化学分析技术检测 TSGF,MEIA法检测 CA12 5、 CA199;检测 182例血清中 (包括卵巢癌10 2例 ,卵巢良性包块 30例 ,正常妇女 5 0例 ) TSGF、 CA12 5及 CA199值 ,并对卵巢癌患者进行治疗前后的 TSGF、CA12 5、CA199值进行监测、随访。结果 卵巢癌患者 TSGF、CA12 5、CA199值及阳性检出率均高于良性肿瘤及正常妇女值 ,单独检测时敏感性分别为 89.2 %、 79.4 %、 4 5 .1% ,联合测定 TSGF和 CA12 5 ,敏感性达 94 .1% ,三项联合则敏感性达 96 .1%。结论 认为联合测定 TSGF、 CA12 5、 CA199有助于提高卵巢癌诊断的敏感性 ,同时对疗效观察及术后监测有重要价值
Objective To investigate the value of combined detection of tumor associated substances detection kit (TSGF), CA12 5 and CA199 in the diagnosis and treatment of ovarian cancer. Methods TSGF, CA12 5 and CA199 were detected by chemical analysis. The serum levels of TSGF, CA12 5 and CA199 were detected in 182 cases of serum (including 102 cases of ovarian cancer, 30 cases of benign ovarian mass, and 50 cases of normal women) The patients with ovarian cancer before and after treatment of TSGF, CA12 5, CA199 values were monitored and followed up. Results The values of TSGF, CA125, CA199 and the positive rate of TSGF, CA12 5 and CA199 in ovarian cancer patients were higher than those in benign tumors and normal women. The sensitivities of TSGF, CA12 5 and CA199 were 89.2%, 79.4% and 45.1% 5, the sensitivity of 94.1%, the three joint sensitivity of 96.1%. Conclusions: Combined determination of TSGF, CA12 5, CA199 contribute to the diagnosis of ovarian cancer sensitivity, while the efficacy of observation and postoperative monitoring of great value