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环丙沙星是一种新型的氟喹诺酮类抗菌药物,其组织分布广,肺组织中药浓度高,副作用少,并具有较强的抗绿脓杆菌活性,是治疗肺部绿脓杆菌感染很有前途的一种药物.我们应用环丙沙星治疗下呼吸道绿脓杆菌感染32例、报告如下.1 临床资料1.1 病例选择 32例中男18例,女14例,年龄18～84岁,平均46岁,均为住院病人.其中肺炎3例、急性肺脓肿4例,慢性支气管炎肺心病并感染8例.支气管扩张并感染3例.肺结核空洞并感染5例,脓胸并肺部感染4例,慢性白血病并肺部感染2例、食道癌并肺部感染2例.所有患者均有咳嗽、咳痰症状(绿脓痰9例,黄脓痰16例,白粘痰7例),伴发热14例(体温37.1～40℃),胸痛5例,咯血3例.肺部体征均有干性或湿性罗音.32例入院前均未使用过环丙沙星,有15例近期未使用过任何抗生素,另17例中9例应用过青霉素,氨苄青霉素,8例应用过头孢唑啉及庆大霉素,治疗无效.入院后而改用环丙沙星.
Ciprofloxacin is a new type of fluoroquinolone antibacterial drugs, its tissue distribution is wide, high concentration of Chinese medicine in lung tissue, less side effects, and has strong anti-Pseudomonas aeruginosa activity is the treatment of pulmonary Pseudomonas aeruginosa infection is very The future of a drug.We use ciprofloxacin treatment of lower respiratory tract Pseudomonas aeruginosa infection in 32 cases, the report is as follows.1 Clinical data 1.1 case selection 32 cases of male 18 cases, 14 females, aged 18 to 84 years, with an average of 46 Year-old, were hospitalized patients, including 3 cases of pneumonia, 4 cases of acute lung abscess, chronic bronchitis and pulmonary heart disease in 8 cases. Bronchiectasis and infection in 3. Pulmonary tuberculosis and infection in 5 cases, empyema and pulmonary infection in 4 cases , Chronic leukemia and pulmonary infection in 2 cases, esophageal cancer and pulmonary infection in 2. All patients had symptoms of cough and sputum (9 cases of green purulent sputum, 16 cases of yellow sputum and 7 cases of white phlegm) with fever 14 cases (body temperature 37.1 ~ 40 ℃), chest pain in 5 cases, hemoptysis in 3. Lung signs were dry or wet rales .32 cases of ciprofloxacin before admission were not used, 15 cases have not been used recently Any antibiotics, the other 17 cases of 9 cases of penicillin, ampicillin, 8 cases of cefazolin and gentamicin, the treatment is invalid Instead of ciprofloxacin after admission.