为探讨ＣＤ１５ 、ｐ５３ 和组织蛋白酶Ｄ（Ｃａｔｈ－ Ｄ）表达与子宫内膜癌侵袭和转移的关系，采用ＳＰ免疫组化法对４０ 例原发性子宫内膜腺癌组织进行了ＣＤ１５、ｐ５３ 和Ｃａｔｈ－ Ｄ检测。结果发现ＣＤ１５ 、ｐ５３ 和Ｃａｔｈ－ Ｄ 在子宫内膜腺癌中阳性率分别为７２－５ ％ 、６５－０ ％ 和６７－５ ％ 。ＣＤ１５ 和ｐ５３ 表达与子宫内膜腺癌的分级、分期有关（ Ｐ ＜０－０５） ，ＣＤ１５ 、ｐ５３ 和Ｃａｔｈ－ Ｄ表达均与肿瘤转移有关（ Ｐ＜ ０－０５） ；强调ＣＤ１５ 、ｐ５３ 和Ｃａｔｈ － Ｄ 表达对判断子宫内膜腺癌的恶性程度、预测肿瘤浸袭转移和评估预后是一种良好指标。 To investigate the relationship between the expression of CD15, p53 and the expression of Cath-D and the invasion and metastasis of endometrial carcinoma, 40 cases of primary endometrial adenocarcinoma were examined by SP immunohistochemistry for CD15, p53 and Cath-D test. The positive rates of CD15, p53 and Cath-D in endometrial adenocarcinoma were 72-5%, 65-0% and 67-5%, respectively. The expression of CD15 and p53 was correlated with the grade and stage of endometrial adenocarcinoma (P <0-05). The expressions of CD15, p53 and Cath-D were correlated with tumor metastasis (P <0-05). CD15, p53 and Cath - D expression is a good indicator for predicting the malignancy of endometrial adenocarcinoma and predicting tumor metastasis and prognosis.