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β1肾上腺素能受体属于G蛋白耦联受体,是心肌细胞最重要的受体之一。既往研究表明,β1肾上腺素能受体通过其相应的信号分子对心脏及心血管功能具有重要的调节作用,近年研究发现,该受体基因水平增高与心力衰竭、高血压等心血管疾病发生、发展及治疗密切相关,其基因甲基化可作为高血压个体化治疗的监测指标,因此对该基因进行深入研究有助于为心血管疾病的早期诊断及个体化治疗提供依据。
Beta 1 adrenergic receptors belong to the G protein-coupled receptor, which is one of the most important receptors in cardiomyocytes. Previous studies have shown that β1 adrenergic receptor through its corresponding signal molecules on cardiac and cardiovascular function has an important regulatory role in recent years found that the receptor gene levels and heart failure, hypertension and other cardiovascular diseases, Development and treatment are closely related to its gene methylation can be used as a monitoring indicator of individualized treatment of hypertension, in-depth study of the gene contribute to the early diagnosis of cardiovascular disease and individualized treatment provide the basis.